(03)00203-6īertocci B, De Smet A, Weill JC, Reynaud CA (2006) Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. J Immunol 162(4):2123–2128īertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (2003) Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. īentolila LA, Olson S, Marshall A, Rougeon F, Paige CJ, Doyen N, Wu GE (1999) Extensive junctional diversity in Ig light chain genes from early B cell progenitors of mu MT mice. Immunol Rev 175:150–157īenichou J, Glanville J, Prak ETL, Azran R, Kuo TC, Pons J, Desmarais C, Tsaban L, Louzoun Y (2013) The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content. īenedict CL, Gilfillan S et al (2000) Terminal deoxynucleotidyl transferase and repertoire development. īaumgarth N (2013) Innate-like B cells and their rules of engagement. īaumgarth N (2011) The double life of a B-1 cell: self-reactivity selects for protective effector functions. Biochem Biophys Res Commun 111:1105–1112īauer K, Hummel M, Berek C, Paar C, Rosenberger C, Kerzel S, Versmold H, Zemlin M (2007) Homology-directed recombination in IgH variable region genes from human neonates, infants and adults: implications for junctional diversity. (02)00675-Xīasu M, Hegde MV et al (1983) Synthesis of compositionally unique DNA by terminal deoxynucleotidyl transferase. īassing CH, Swat W, Alt FW (2002) The mechanism and regulation of chromosomal V(D)J recombination. Īvnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA (2016) IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Īoki-Ota M, Torkamani A, Ota T, Schork N, Nemazee D (2012) Skewed primary Igkappa repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. The processes that contribute to repertoire formation may appear to be stochastic, but in both species, evolution has left little to chance.Īlanio C, Lemaitre F, Law HK, Hasan M, Albert ML (2010) Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies. We propose that it is the differences in the naïve repertoires of mice and humans, and the differences in the ways these repertoires are used, which ensure that the very different biological needs of the two species are met. Species like the mouse face challenges that are a direct consequence of their small body sizes and the limitations this places on the antibody arsenal-particularly early in ontogeny. By skewing repertoire formation toward such sequences, which probably target commonly encountered pathogens, it may be that the relatively small mouse repertoire is appropriate and effective despite its size. These clonotypes are the result of gene rearrangements that involve little gene processing. We show that the mouse repertoire includes a conspicuous population of public clonotypes that are shared by different individuals of an inbred strain. In this review, features of the naïve antibody repertoires of the two species are contrasted. The repertoires of mice and humans are both predictable, but they are strikingly different. Recently, however, analysis of high throughput gene sequencing data has shown that hard-wired biases in these processes result in antibody repertoires that are broadly predictable. Repertoire diversity has been described as the “miracle of immunology,” and it was long thought to be the result of essentially stochastic processes. The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities.
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